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14-3-3 Testing in Diagnosing Creutzfeldt-Jakob Disease Neurol 55:514-516, Lemstra,A.W. et al, 2000 See this aricle in Pubmed Article Abstract The sensitivity was 97% and the specificity was 87% in this series. False-positive results were mainly caused by stroke and meningoencephalitis. The 14-3-3 protein is a highly sensitive and specific marker for CJD when used in the appropriate clinical context.

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